Peer-reviewed government and assocation grants

Research Projects supported by industry sources

Australian and international collaborative research projects

RESEARCH PROJECTS generated from competitive peer-reviewed government and assocation grants

The role of connective tissue growth factor in the extracellular matrix metabolism in the rheumtoid synovium
Smith MM
[The Lincoln Centre for Research into Bone & Joint Diseases - 2004]

Why is trophoblast invasion defective in human pregnancies that develop pre-eclampsia?
Gallery E, Jackson C and Morris J
[National Health and Medical Research Council (NHMRC) - pending 2004]

Perlecan maintains the chondrocyte phenotype in vivo and promotes cartilage growth/repair
Melrose J, Whitelock J, Dart A, Lyons G, Jackson C and Sonnabend D
[National Health and Medical Research Council (NHMRC) - pending 2004]

The mechanism and modulation of tendon invasion by tenosynovium in rheumatoid arthritis
Nanchahal J, Jackson C, Melrose J, Smith M and March L
[National Health and Medical Research Council (NHMRC) - pending 2004]

Activated protein C as a promoter of wound healing
Jackson C, Xue M, Whitmont K, Cooper A and March L
[National Health and Medical Research Council (NHMRC) Development Grant - 2003 - 05]

The role of activated protein C in the destruction of the arthritic joint
Buisson-Legendre N and Jackson C
[Lincoln Centre for Research into Bone and Joint Disease - 2003]

Activated protein C to prevent the onset and the development of type 1 diabetes in non-obese diabetic (NOD) prone mice Xue M, Gallery E, Clifton-Bligh R and Jackson C
[Northern Sydney Area Health Service Research Fund - 2003 -4]

Elucidating the regulartory mechanisms of gelatinase activity by arthritis cells
Jackson C, Zoe Cassidy, Buisson-Legendre N and Sambrook P
[Rebecca Cooper Medical Research Foundation - 2003]

In vitro studies into the mechanisms of action of activated protein C
Jackson C
[Vice-chancellor's Seeding Grant, University of Sydney - 2002 - 03]

Development of evidence-based guidelines for management of acute musculoskeletal pain
Brooks P, March L, Bogduk N and Bellamy N
[Commonwealth Department of Health and Aged Care - 2003 - 03]

Arthritis C.O.S.T. (Costs and Outcomes of Surgery and other Treatments) study
March LM, Lapsely H and Brooks PM
[National Health and Medical Research Council (NHMRC) 2002 - 04]

Epidemiology of osteoporotic fractures in the frail elderly - Extension
Sambrook P, March L and Cumming R
[National Health and Medical Research Council (NHMRC) 2002 - 04]

Investigations on the regulation of intervertebral disc cell matrix metalloproteinases
Melrose J and Ghosh P
[National Health and Medical Research Council (NHMRC) 2002 - 04]

Are evidence based care pathways cost effective in reducing fracture risk
Department of Rheumatology
[Arthritis Foundation of Australia - pending 2002]

Studies on the role of cartilage components and growth factors in the pathogenesis of osteoarthritis (for the purchase of equipment: Microtome)
Ghosh P, Melrose J, Smith S and Whitelock J
[Rebecca L Cooper Medical Research Foundation - pending 2002]

Prevention of injuries in older people
Lord S, Anstey K, Bashford G, Bliokas V, Broe A, Eauman A, Clark R, Cameron ID, Carney L, Courtney M, Creasey H, Cumming R, Edwards H, Evands D, Evans J, Fitzpatrick R, Halmagyi M, Hodges P, Keer G, Kuys S, March L, Menz H, Mitchel P, Munro B, Newman B, Ni S, Ogle S, Oldenburg B, Parker A, Pearson A, Salgado R, Sherrington C, Silburn P, Smith G, Steele J, Varghese P, Wood J, Williams M, Worringham C
[National Health and Medical Research Council (NHMRC) - partnership 2001 - 05]

Development and implementation of evidence-based guidelines for acute treatment and rehabilitation of hip fracture: A randomised controlled intervention
March L, Sambrook P and Cameron I
[Medical Benefit Fund Health Research Awards, Australia - 2000 - 02]

Department of Rheumatology
[Arthritis Foundation of Australia - 2001]

Relationship between oestrogen receptor levels and hyaluronan biosynthesis by synovial fibroblasts derived from joints of females with osteoarthritis
Ghosh P, Smith MM and Coolican MRJ
[Australian Orthopaedic Association of Australia - 2001]

Research magnetic resonance imaging instrument
Sambrook P, Ghosh P and Hunter D
[Large Equipment Grants (University of Sydney) - 2001]

The effects of oestrogen replacement therapy on oestrogen receptor levels in synovial fibroblasts derived from joints of an ovine model of osteoarthritis
Ghosh P and Smith MM
[Northern Sydney Area Health Service Research Fund - 2000 - 01]

Epidemiology of osteoporotic fractures in the frail elderly
Sambrook P, March L, Cumming R and Cameron I
[National Health and Medical Research Council (NHMRC) - 1999 - 2001]

Epidemiology of osteoporotic fractures in very frail older people: Risk factors, quality of life and mortablity
Sambrook P, March L, Cameron ID and Cumming R
[National Health and Medical Research Council (NHMRC) - 1999 - 2001]

Mechanisms of disc degeneration in the lumbar spine
Ghosh P, Melrose J and Taylor TKF
[National Health and Medical Research Council (NHMRC) - 1999 - 2001]

Phase I: Isolation and preparation of pharmaceutical quality chondroitin sulphate from bovine trachlea (Meat Industry Co-produced Biologicals)
Ghosh P, Pattison S and Todd B
[Meat and Livestock Authority - 1999 - 2001]

The role of hyperglycaemia and hypoxia in mediating cytokine responses in diabetic nephropathy
Pollock C, Field M and Jackson C
[National Health and Medical Research Council (NHMRC) - 1999 - 2001]

The effects of high and low dose oestrogen on cartilage proteoglycan metabolism in an ovine model of osteoarthritis
Ghosh P, Engle M, Hwa S-Y and Burkhardt D
[Australian Orthopaedic Association of Australia - 2000]

Clinical pathways for fractured neck of femur
March L, Sambrook P and Cameron I
[Medical Benefit Fund Health Research Awards, Australia - 1999 - 2000]

The effects of oestrogen and Tamoxifen on the bone mineral density, bone toughness and cartilage viscoelastic properties in an ovine model of osteoarthritis
Ghosh P, Swain M and Clifton-Bligh P
[Northern Sydney Area Health Service Research Fund - 1999 - 2000]

The role of oestrogen in the pathogenesis of osteoarthritis
Ghosh P and Li W
[World Health Organisation (via Health and Aged Care, Department of Health, Canberra) - 1999 - 2000]

Mechanisms of corticosteroid osteoporosis
Sambrook PN, Mason RS and Robinson BG
[National Health and Medical Research Council (NHMRC) - 1998 - 2000]

NHMRC Centre of Clinical Excellence
Cousins M, Mathers L, Nicholas M, March L, et al.
[National Health and Medical Research Council (NHMRC) - 1998 - 2002]

Multiple projects - Department Rheumatology
[Arthritis Foundation of Australia - 1996 - 2000]

Cost and cost effectiveness of joint replacement in arthritis
(conjoint with University of New South Wales)
Brooks PM, March LM and Lapsley H
[National Health and Medical Research Council (NHMRC) - 1994 - 2000]

RESEARCH PROJECTS supported by industry sources

Synvisc, MRI, clinical and laboratory studies
March L and Ghosh P, Baggah H and Sambrook PN
[Bayer Australia 2001-03]

Dose escalation studies on the relative effects of hyaluronan and hyaluronan derivatives on cartilage integrity and synovial cell metabolism in an ovine model of osteoarthritis
Ghosh P and Read R
[DePuy (United Kingdom) 2001 - 02]

Studies on the effects of intra-articular injection of hyaluronans on the viscoelasticity of synovial fluid and synovial cell metabolism
Ghosh P and Read R
[Fidia S.p.A. (Italy) 2000 - 01]

Fracture risk epidemiology in the frail elderly - Effect on quality
of life
Sambrook PN, March L, Cameron I and Cumming R
[Lilly Asian Pacific Womens Health Program 2002]

Characterisation and biological evaluation of glycosaminoglycans from bovine trachael cartilage
Ghosh P and Shen B
[Chondrotec Pty. Limited 2001 - 02]

Australian Rheumatoid Arthritis Data Base (ARAD)
March L
[Aventis 2001]

Etancercept in the treatment of rheumatoid arthritis: Comparison with sulpasalazine and methotrexate
Sambrook PN and March L
[Wyeth 2001]

Risedronate in undiagnosed osteoporosis: Impact of bone markers on compliance
Sambrook PN
[Aventis 2001]

Molecular biology of gene products derived from deer antler cartilage cells
Ghosh P and Roubin R
[ADP Pharmaceuticals Pty. Limited (Goulburn, Australia) 2000 - 01]

Preclinical and clinical evaluation of pentosan polysulphate
Ghosh P
[Arthropharm Pty. Limited (Sydney, Australia) 2000 - 01]

Mechanisms of angiogenesis in the intervertebral disc
Taylor TKF and Ghosh P
[Sofamor Danek Australia Pty. Limited 2000 - 01]

AUSTRALIAN and INTERNATIONAL COLLABORATIVE RESEARCH PROJECTS

The effect of meniscectomy on gene expression by knee ligaments
Smith MM and Hart DA [McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Canada]

Advancement of tibial tuberosity to establish animal model of chondromalacia patellae in sheep
Hwa S-Y [Department of Orthopaedics, Tri-Service General Hospital, Taipei, Taiwan], Ghosh P, Read R [Department of Veterinary Sciences, Murdoch University, WA] and Cake M [Department of Veterinary Sciences, Murdoch University, WA]

Assessment of the sub-structure, adhesive properties and growth factor binding capabilities of perlecan immunopurified from a range of cell sources including intervertebral disc cells
Melrose J, Whitelock J [CSIRO Molecular Sciences, North Ryde, NSW], Knox S [CSIRO Molecular Sciences, North Ryde, NSW] and Underwood A [CSIRO Molecular Sciences, North Ryde, NSW]

Biomechanical, histological and immunohistological studies of joint cartilage in an ovine model of osteoarthritis induced by lateral meniscectomy
Ghosh P, Appleyard RC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW] and Swain MV [Biomaterials Research Science Unit, University of Sydney]

Effect of sex hormones and disease modifying drugs on the dynamic biomechanical and histological properties of joint cartilages in an ovine model of osteoarthritis induced by meniscectomy
Ghosh P, Appleyard RC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW], Murrell GC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW], Swain MV [Biomaterials Research Science Unit, University of Sydney], Cake M [Department of Veterinary Sciences, Murdoch University, WA] and Read R [Department of Veterinary Sciences, Murdoch University, WA]

Histochemical assessment of extracellular matrix changes in an ovine annular lesion model of experimental intervertebral disc degeneration
Melrose J, Smith S, Kitson J [Connective Tissue Biology Laboratories, University of Wales at Cardiff, UK], Little C [Connective Tissue Biology Laboratories, University of Wales at Cardiff, UK], Hwa S-Y, Ghosh P, Taylor TKF and Rai A

Histological assessment of new blood vessel development and penetration of nerves into annular defects in an ovine annular lesion model of experimental disc degeneration
Melrose J and Roberts S [and colleagues of the Centre for Spinal Studies, Agnes Hunt Orthopaedic Hospital, Oswestry, England and Cardiff School of Biosciences, Cardiff University, Wales, UK]

Longitudinal studies on biochemical and histological properties of cartilage, subchondral bone and synovial fluid in an ovine model of osteoarthritis
Ghosh P, Read R [Murdoch University, Perth, WA], Swain M [Biomaterials Research Science Unit, University of Sydney], Appleyard RC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW], Smith MM, Burkhardt D and Murrell GC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW]

MRI cartilage volume measurement
Hunter D and Warfield S [Surgical Planning Laboratory, Brigham and Women's Hospital, Boston, USA]

Studies on tissue inhibitor of metalloproteinases 3 and the effects of calcium pentosan polysulfate in human rheumatoid synovial fibroblasts
Ghosh P, Takizawa M [University of Keio, Tokyo, Japan], Ohuchi E [University of Keio, Tokyo, Japan], Nakamura H [University of Keio, Tokyo, Japan], Ikeda E [University of Keio, Tokyo, Japan] and Okada Y [University of Keio, Tokyo, Japan]

Surrogate markers for monitoring disease progression in osteoarthritis
Ghosh P, Smith MM and Verbruggen G [Department of Rheumatology, Ghent University, Ghent, Belgium]

The epidemiologic and demographic characteristics of adolescent idiopathic scoliosis, Scheuermann's disease and congenital spinal abnormalities
Taylor TKF, Robertson P [Department of Orthopaedics, Auckland University], Cumming R [Department of Public Health and Community Medicine, University of Sydney], Jones F [Department of Sociology, Australian National University], MacCann R [Head of Measurement and Research Services, Board of Studies], March L, deSouza FK, Plunkett-Cole M and Bleasel J [Department of Rheumatology, Rachel Foster Hospital]

The role of estrogen replacement therapy on estrogen receptor and hyaluronan expression in human synoviocytes and chondrocytes from joint tissues of menopausal females with osteoarthritis
Ghosh P, Smith M and Coolican M

Topographical quantitative biomechanical studies of chondromalacia patellae
Hwa S-Y [Department of Orthopaedics, Tri-Service General Hospital, Taipai, Taiwan], Ghosh P, Appleyard RC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW] and Swain M [Biomaterials Research Science Unit, University of Sydney]

Twin studies of osteoarthritis and osteoporosis
Sambrook P, Hunter D and Spector T [Twin Research Unit, St Thomas' Hospital, London, UK]

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