IBJ > Research > Collaborative research

Collaborative research

Australian and international collaborative research projects
Information regarding contractual research

In recent years collaborative projects with other Institutes and national and international companies have been established to promote the outcomes of our research and facilitate its commercialization.

The Institute welcomes all inquires of collaborations for groups working in the area of musculoskeletal sciences.

AUSTRALIAN and INTERNATIONAL COLLABORATIVE RESEARCH PROJECTS

The effect of meniscectomy on gene expression by knee ligaments
Smith MM and Hart DA [McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Canada]

Advancement of tibial tuberosity to establish animal model of chondromalacia patellae in sheep
Hwa S-Y [Department of Orthopaedics, Tri-Service General Hospital, Taipei, Taiwan], Ghosh P, Read R [Department of Veterinary Sciences, Murdoch University, WA] and Cake M [Department of Veterinary Sciences, Murdoch University, WA]

Assessment of the sub-structure, adhesive properties and growth factor binding capabilities of perlecan immunopurified from a range of cell sources including intervertebral disc cells
Melrose J, Whitelock J [CSIRO Molecular Sciences, North Ryde, NSW], Knox S [CSIRO Molecular Sciences, North Ryde, NSW] and Underwood A [CSIRO Molecular Sciences, North Ryde, NSW]

Immunolocalisation of perlecan (red chromogen) using monoclonal antibody A76 to perlecan domain-I in primordial cartilage of the developing human spine (14 week). vb-vertebral body, np-nucleus pulposus, af-annulus fibrosus. Low power macroscopic view, sagittal section

Biomechanical, histological and immunohistological studies of joint cartilage in an ovine model of osteoarthritis induced by lateral meniscectomy
Ghosh P, Appleyard RC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW] and Swain MV [Biomaterials Research Science Unit, University of Sydney]

Effect of sex hormones and disease modifying drugs on the dynamic biomechanical and histological properties of joint cartilages in an ovine model of osteoarthritis induced by meniscectomy
Ghosh P, Appleyard RC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW], Murrell GC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW], Swain MV [Biomaterials Research Science Unit, University of Sydney], Cake M [Department of Veterinary Sciences, Murdoch University, WA] and Read R [Department of Veterinary Sciences, Murdoch University, WA]

Histochemical assessment of extracellular matrix changes in an ovine annular lesion model of experimental intervertebral disc degeneration
Melrose J, Smith S, Kitson J [Connective Tissue Biology Laboratories, University of Wales at Cardiff, UK], Little C [Connective Tissue Biology Laboratories, University of Wales at Cardiff, UK], Hwa S-Y, Ghosh P, Taylor TKF and Rai A

Histological assessment of new blood vessel development and penetration of nerves into annular defects in an ovine annular lesion model of experimental disc degeneration
Melrose J and Roberts S [and colleagues of the Centre for Spinal Studies, Agnes Hunt Orthopaedic Hospital, Oswestry, England and Cardiff School of Biosciences, Cardiff University, Wales, UK]

Longitudinal studies on biochemical and histological properties of cartilage, subchondral bone and synovial fluid in an ovine model of osteoarthritis
Ghosh P, Read R [Murdoch University, Perth, WA], Swain M [Biomaterials Research Science Unit, University of Sydney], Appleyard RC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW], Smith MM, Burkhardt D and Murrell GC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW]

MRI cartilage volume measurement
Hunter D and Warfield S [Surgical Planning Laboratory, Brigham and Women's Hospital, Boston, USA]

Studies on tissue inhibitor of metalloproteinases 3 and the effects of calcium pentosan polysulfate in human rheumatoid synovial fibroblasts
Ghosh P, Takizawa M [University of Keio, Tokyo, Japan], Ohuchi E [University of Keio, Tokyo, Japan], Nakamura H [University of Keio, Tokyo, Japan], Ikeda E [University of Keio, Tokyo, Japan] and Okada Y [University of Keio, Tokyo, Japan]

Surrogate markers for monitoring disease progression in osteoarthritis
Ghosh P, Smith MM and Verbruggen G [Department of Rheumatology, Ghent University, Ghent, Belgium]

The epidemiologic and demographic characteristics of adolescent idiopathic scoliosis, Scheuermann's disease and congenital spinal abnormalities
Taylor TKF, Robertson P [Department of Orthopaedics, Auckland University], Cumming R [Department of Public Health and Community Medicine, University of Sydney], Jones F [Department of Sociology, Australian National University], MacCann R [Head of Measurement and Research Services, Board of Studies], March L, deSouza FK, Plunkett-Cole M and Bleasel J [Department of Rheumatology, Rachel Foster Hospital]

The role of estrogen replacement therapy on estrogen receptor and hyaluronan expression in human synoviocytes and chondrocytes from joint tissues of menopausal females with osteoarthritis
Ghosh P, Smith M and Coolican M

Topographical quantitative biomechanical studies of chondromalacia patellae
Hwa S-Y [Department of Orthopaedics, Tri-Service General Hospital, Taipai, Taiwan], Ghosh P, Appleyard RC [Orthopaedic Research Institute, St. George Hospital Campus of the University of NSW] and Swain M [Biomaterials Research Science Unit, University of Sydney]

Twin studies of osteoarthritis and osteoporosis
Sambrook P, Hunter D and Spector T [Twin Research Unit, St Thomas' Hospital, London, UK]

Dr Shen using FPLC

Dr Shen using FPLC to separate and identify components of the articular cartilage matrix

INFORMATION REGARDING CONTRACTUAL RESEARCH

IBJ welcomes inquires from companies and other organizations who are interested in utilizing the Institute's experienced staff to undertake basic and clinical research into musculoskeletal diseases and disorders, particularly in relation to their diagnosis and treatments.

The IBJ has already completed a number of projects with Australian and international pharmaceutical company and prosthetic manufacturers to evaluate the clinical and pre-clinical effectiveness of their products using our animal models as well as in patients.

More recent projects are underway to validate non-invasive techniques of disease modification in osteoarthritic (OA) joins using micro resonance imaging (MRI) and biochemical markers. This research is being undertaken in collaboration with laboratories in the United Kingdom and United States of America.

For further inquires and information, please contact Professor Philip Sambrook.