IBJ > Research > Ongoing research

Ongoing research

Mr Burkhardt harvesting a fragment of a histological section

Mr Burkhardt harvesting a fragment of a histological section for the determination of the biochemical composition of articular cartilage

CURRENT RESEARCH PROJECTS generated from competitive peer-reviewed government and association grants

Investigators     Sambrook PN, March L, Cameron I, Cumming R, Seibel M, Mason R, Simpson J
Title                 FREEDOM Study
Period              2006-2008
Funds              $ 810,000
Source             NHMRC

Investigators     Cumming R, Handelsman D, Seibel M, Creasey H, Sambrook PN, Waite L
Title                 CHAMP Study
Period              2004-2008
Funds              $1,720,000
Source             NHMRC

Investigators     C Jackson, M Xue, P Sambrook
Title                 Inflammation in arthritis
Period              2006-10
Funds              $100,000
Source             Rebecca Cooper Foundation

Investigators     C Jackson, M Xue, L. Harrison
Title                 Prevention of type 1 diabetes
Period              2008
Funds              US$102,000
Source             Juvenile Diabetes Research Foundation International

Investigators     M Xue
Title                 Treatment for rheumatoid arthritis
Period              2008-10
Funds              $368,000
Source             NHMRC CDA award

Investigators     M Xue, C Jackson
Title                 APC to treat arthritis
Period              2008-10
Funds              $50,000
Source             near miss NHMRC, University of Sydney

Investigators     C Jackson, M Xue
Title                 Mechanisms underlying a new treatment for wound healing
Period              2008-10
Funds              $346,000
Source             NHMRC

Investigators     C Jackson, M Xue, A Cooper, G Fulcher, P Sambrook, L March
Title                 Clinical trial- Activated protein C to treat chronic wounds
Period              2006-10
Funds              $150,000
Source             Medical Research Foundation, University of Sydney, NHMRC near-miss grant

Investigators     Fosang AJ and Little CB
Title                 How important is collagen destruction in arthritis?
Period              2006-2008
Funds              $518,700
Source             NHMRC project grant 400056

Investigators     Bateman J, Little CB and Fosang AJ
Title                 Mechanisms of cartilage breakdown in osteoarthritis.
Period              2006-2008
Funds              $448,500
Source             NHMRC project grant 384414

Investigators     Little CB, Sonnabend DH, Appleyard RC, Melrose J and Fosang AJ
Title                 Proteoglycan metabolism in tendon degeneration.
Period              2006-2008
Funds              $460,950
Source             NHMRC project grant 402626

Investigators     Little CB
Title                 Examining the pathophysiology and treatment of surgically-induced osteoarthritis in                        genetically modified mice
Period              2008-2010
Funds              $318,889
Source             Pfizer Inc.

Investigators     J Melrose, A Hayes, J Whitelock, R Appleyard, CB Little
Title                 The role of Perlecan in Tensional Tissues
Period              2008-2010
Funds              $580,500
Source             NHMRC Project Grant 512167

Investigators     J Melrose, CB Little
Title                 An-in vivo model of meniscal degeneration initiated by inflammatory cytokines
Period              2008
Funds              $45,000
Source             Arthritis Australia Jack Bloomfield Grant

Investigators     Young AA, Sonnabend DH, Little CB, Smith MM
Title                 Modulation of Rotator Cuff Tendinopathy by Corticosteroids or Stem Cells – A Pilot                        Study
Period              2008
Funds              $29,000
Source             Australian Orthopaedic Association

Investigators     Little CB, Sonnabend DH
Title                 Stem Cells to treat tendon disease
Period              2008
Funds              $50,000
Source             The Hillcrest Foundation

Investigators     Little CB, Jackson CJ
Title                 Novel pathways involving APC and PAR-2 in cartilage degradation in osteoarthritis
Period              2009-2011
Funds              $431,000
Source            NHMRC Project Grant (570921)

Investigators     Little CB, Smith MM, Sonnabend DH, Appleyard RC, Melrose J, Hunyor S
Title                 Stem cell treatment for tendon degeneration
Period              2009-2011
Funds              $659,500
Source             NHMRC Project Grant (570922)

Investigators     Little CB
Title                 Histology and immunohistology of large bone and joint tissue specimens.
Period              2009
Funds              $16,545
Source             Rebecca Cooper Medical Research Foundation

Ms Shimmon using BIACore technology

Ms Shimmon using BIACore technology to analyse experimental drugs interactions with enzymes